Overcoming the Hurdles to Oral Peptide Development
Peptide therapeutics have the potential to become blockbusters on a scale that was previously seen within the monoclonal antibody space thanks to their effectiveness and biocompatibility. However, peptides also present a variety of development hurdles, particularly for oral delivery, as they are susceptible to hydrolysis and enzymatic degradation and have poor bioavailability. Therefore, converting a highly predictable, 100% bioavailable injectable peptide into a robust OSD form remains challenging.
For the latest From Stem to Stern episode, The Pharma Navigator sat down with a panel of experts from Alcami to find out more about the formulation strategies, alternative manufacturing approaches, and analytical testing updates available to overcome the obstacles to oral peptide therapeutic development. The panel for this episode comprised: Robert Sciscento, Senior Scientist, Formulation Development, OSD; Trevor Williams, Senior Scientist, Formulation Solid Dosage; and Zachary Morseth, Manager — Bioseparations/Mass Spectrometry, all from Alcami.
As poor solubility continues to plague development pipelines, alternative biocompatible permeation enhancers are becoming increasingly beneficial for formulation scientists notes Roger Viney from ICE Pharma.
Codis Expands Spray Drying Capability Through Catalent Facility Acquisition
The move to acquire Catalent’s Nottingham facility strengthens Codis’ integrated CDMO model, linking formulation, spray drying, and commercial-scale production within a single supply chain.
Lonza Targets Blood–Brain Barrier Challenge with Nona Biosciences Deal
Through acquiring the rights to Nona Biosciences’ TfR1 BBB technology and expanding its strategic collaboration with the company, Lonza is broadening its capabilities to support customers developing next-gen CNS therapies.
In Vivo Cell Engineering & Gene Editing Summit 2026
Date: July 28-30, 2026
Location: Boston, USA
Tumor Models Summit 2026
Date: July 29-30, 2026
Location: Boston, USA
Bioprocessing Summit 2026
Date: August 10-13, 2026
Location: Boston, USA
Share your story with The Pharma Navigator
If your company has news, insights, or a press release that deserves a wider audience, we'd love to feature it in an upcoming edition of The Pharma Navigator.
Get in touch to be considered for a future feature.
Navigator Media Ltd, Chester Steam Mill, Steam Mill Street, Chester, Cheshire CH3 5AN, United Kingdom
